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Article posted Jun 28 2007, 2:02 AM Category: Health Source: Sydney Morning Herald Print

Aspartame linked to cancer: study


The US Food and Drug Administration says there is no need for an urgent review of the safety of aspartame, despite a new study showing the sweetener may cause cancer.

A US consumer group has called for the review after Italian researchers published a new study that showed aspartame - widely used in soft drinks - might cause leukaemia, lymphoma and breast cancer in rats.

"This is the second study by the same lab showing that aspartame causes cancer in rats," Centre for Science in the Public Interest executive director Michael Jacobson said.

Aspartame is used mostly in soft drinks but is also sold in packets to use in coffee, tea or on food.

Morando Soffritti of the Ramazzini Foundation in Bologna, Italy, and colleagues tested aspartame in rats, which they allowed to live until they died naturally.

Their study of more than 4,000 rats showed a lifetime of eating high doses of the sweetener raised the likelihood of several types of cancer.

"On the basis of the present findings, we believe that a review of the current regulations governing the use of aspartame cannot be delayed," Soffritti's team wrote in the journal Environmental Health Perspectives, which is published by the US National Institute of Environmental Health Sciences.

"This review is particularly urgent with regard to aspartame-containing beverages, heavily consumed by children."

FDA spokesman Michael Herndon said the agency had not yet reviewed the study.

"However, the conclusions from this second European Ramazzini Foundation are not consistent with those from the large number of studies on aspartame that have been evaluated by FDA, including five previously conducted negative chronic carcinogenicity studies," Herndon said in an email.

"Therefore, at this time, FDA finds no reason to alter its previous conclusion that aspartame is safe as a general purpose sweetener in food."

Jacobson said researchers in previous studies all killed rats at the age of two years.

Allowing the rats to live longer may have been a better way to assess the natural risk of cancer, he said.

The CSPI said the Acceptable Daily Intake of aspartame in the United States was 50 mg per kilogram of body weight, equivalent to a 20 kg child drinking 2.5 cans of diet soft drink a day, or a 68 kilogram adult drinking about 7.5 cans a day.

The Italian researchers found a cancer risk at the very highest doses - double the US Acceptable Daily Intake.

Merisant, which makes Equal, said in a statement on its website: "The safety of aspartame has been confirmed by regulatory authorities in more than 100 countries, including the US Food and Drug Administration, Health Canada, and the European Commission's Scientific Committee on Food, as well as by experts with the United Nations' Food and Agricultural Organisation and World Health Organisation."

Jacobson said people should avoid the product for now.

"People shouldn't panic, but they should stop buying beverages and foods containing aspartame," he advised.





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